1+ mon, 2+ week ago   (244+ words) Among 459 cognitively unimpaired women aged 65 to 80 years, hormonal contraceptive use and later menopause were associated with greater gray matter volume and cortical thickness in selected brain regions. Greater lifetime exposure to ovarian hormones was associated with brain structure measures generally…...

1+ mon, 2+ week ago   (361+ words) Researchers found greater reductions in body mass index and participant-reported hunger scores with setmelanotide than with placebo, although adverse and serious adverse events were more frequent in the setmelanotide group; only one serious adverse event was considered treatment-related. Setmelanotide was…...

1+ mon, 3+ week ago   (217+ words) Remote assessments detected memory changes over 30 weeks in patients with mild cognitive impairment, whereas conventional neuropsychological testing did not detect differences in short-term decline. In contrast, conventional neuropsychological testing was not sensitive to differences in short-term decline. In a subgroup…...

1+ mon, 4+ week ago   (228+ words) Researchers developed the MDM System, which assigns one point for each metabolite exceeding the highest value observed in the typically developing reference group. Children with ASD had an average MDM total score of 3.3, while all typically developing children scored zero....

2+ mon, 4+ day ago   (8+ words) Conexiant...

2+ mon, 2+ week ago   (572+ words) Effects varied by which biomarker and diet were measured, and the study stops short of proving diet changes risk. Older adults with elevated blood biomarkers of Alzheimer disease pathology or broader neurobiological risk who more closely adhered to a diet…...

2+ mon, 1+ week ago   (484+ words) In two population-based cohorts, metabolically unhealthy status generally showed higher dementia risk estimates, while metabolically healthy obesity was not associated with increased risk in primary analyses. Patients classified as metabolically unhealthy generally had higher dementia risk estimates regardless of obesity…...

2+ mon, 1+ week ago   (326+ words) A meta-analysis of placebo-controlled crossover trials found reduced aerobic time-trial completion times with both low- and moderate-dose oral anhydrous caffeine, but the evidence was mostly derived from male participants, cycling studies, and trials using doses no higher than 6 mg/kg....

2+ mon, 3+ week ago   (134+ words) Conexiant This Neuroscience Grand Rounds session, led by Ruying Fu, MD, highlights evidence-based strategies for acute, preventive and interventional migraine management in pediatric patients Migraine care requires a comprehensive approach, combining rapid symptom relief with therapies that reduce frequency and…...

2+ mon, 3+ week ago   (275+ words) Plasma proteomic models of more than 40 cell types were associated with incident Alzheimer's disease, amyotrophic lateral sclerosis, cancer, and mortality across three large cohorts. Plasma proteomic signatures of aging at the cellular level could be associated with future disease and…...