2+ day, 1+ hour ago   (290+ words) Jeffrey Hyams, MD, of the University of Connecticut and Connecticut Children’s Hospital in Hartford, Connecticut, shares results from the UNIFI JR trial evaluating ustekinumab in pediatric patients with ulcerative colitis who did not respond to conventional therapies. From these results…...

2+ day, 1+ hour ago   (427+ words) The following transcript has been edited for clarity. Can you elaborate a little on what the results tell us about survodutide’s unique dual glucagon/GLP-1 mechanism? Dr. Le Roux: Yeah, because survodutide acts like an oxyntomodulin analog, a natural gut…...

3+ day, 18+ hour ago   (294+ words) The development of immune checkpoint inhibitors, specifically pembrolizumab used alone or in combination with chemotherapy, has improved outcomes for selected patients with triple-negative breast cancer (TNBC). Despite this success, patients still develop primary or acquired resistance. In a recent review…...

1+ week, 4+ day ago   (350+ words) Cindy Zadikoff, MD, MSc, executive medical director at AbbVie, discusses recent results of the TEMPO-2 trial. Here, she shares what tavapadon use means for clinicians treating early Parkinson’s disease, how to balance tolerability and efficacy in clinical practice, the drug’s…...

2+ week, 4+ day ago   (213+ words) Huntington’s disease (HD) involves disruption in brain cholesterol homeostasis, with several HD animal models showing reduced brain cholesterol biosynthesis and levels. Providing exogenous cholesterol has been effective for improving phenotypes, but the existing methods used to deliver cholesterol are invasive…...

3+ week, 3+ day ago   (226+ words) Therapies currently used to treat myasthenia gravis (MG) are limited by their short-term efficacy and may not be readily available in plasma exchange settings. In light of this, other approaches to treating MG are needed. In a prospective study published…...

3+ week, 3+ day ago   (221+ words) The study, conducted in the second year of vaccine distribution, included 639 individuals selected from the German general population. Participants had a mean age of 37.04 years, 77.8% were female, and 24.4% self-reported a mental illness. Initially, 715 individuals participated in the study, but 76 were…...

3+ week, 4+ day ago   (521+ words) Docwire News Inflammatory Bowel Disease and Psychiatric Comorbidities A cohort study of Swedish patients with inflammatory bowel disease (IBD) found an increased risk of any psychiatric disorder from 2 to 3 years before diagnosis through 10 years after. There is evidence to suggest…...

1+ mon, 2+ day ago   (115+ words) In a cohort study, investigators found that respiratory tract infections early in life are associated with development of atopic dermatitis in childhood. In VDAART, children in the upper tertiles of infection episodes and days, had higher risk for atopic dermatitis…...

1+ mon, 1+ week ago   (213+ words) A phase 2 trial of the melanocortin-4 receptor agonist setmelanotide in patients with acquired hypothalamic obesity (aHO) showed evidence of substantial weight loss. However, further research is still needed to understand the safety and efficacy of the drug. In a phase…...