2+ day, 1+ hour ago   (388+ words) In this GEN webinar, two experts will discuss the growing role of ddPCR in clinical research and translational oncology. The post Highly Multiplexed Droplet Digital PCR for Ultra-Sensitive NSCLC Biomarker Detection in Research Workflows appeared first on GEN - Genetic Engineering…...

2+ day, 3+ hour ago   (361+ words) A Salk Institute team has now discovered a novel pathway that links chronic interferon II (IFN-II) exposure to mitochondrial dysfunction that ultimately causes immunosuppression. By explaining how interferon II turns from “good” to “bad,” the foundational insights provide a path…...

3+ day, 2+ hour ago   (332+ words) Globally, the incidence of newly diagnosed cancer cases is projected to increase over the next decade.1 Despite advancements in personalized medicine and therapeutic options, cancer diagnoses remain challenging. Many patients are diagnosed at advanced stages (III/IV) when the disease has…...

4+ day, 38+ min ago   (485+ words) Genetic Engineering and Biotechnology News For decades, RAS proteins have occupied a frustrating place in cancer biology: central to tumor growth, yet difficult to drug. Members of the RAS family—KRAS, NRAS, and HRAS—act as molecular switches that help…...

1+ week, 3+ day ago   (485+ words) Loss of function in the ALDH3B2 gene can convert human pancreatic duct cells into functional β-like cells that in tests secreted insulin in response to glucose, and lowered blood glucose levels when transplanted into diabetic mice. The post Human Pancreatic Duct…...

1+ week, 3+ day ago   (529+ words) genengnews.com A study by researchers at Harvard Medical School has shown that loss of function in the aldehyde dehydrogenase family 3 member B2 (ALDH3B2) gene can convert human pancreatic duct cells into functional β-like cells that can secrete insulin in response to…...

1+ week, 4+ day ago   (244+ words) A study by scientists at the Morgridge Institute for Research has demonstrated how an advanced imaging technique, optical metabolic imaging (OMI) can be used to characterize metabolic activity within immune cells from the peripheral blood of patients, which the researchers…...

1+ week, 5+ day ago   (475+ words) Triple-negative breast cancer (TNBC) may initially respond well to chemotherapy but will often develop resistance to treatment. Researchers at Medical University of South Carolina Hollings Cancer Center have now uncovered one of the mechanisms behind that resistance and a potential…...

2+ week, 1+ day ago   (206+ words) This work is published in Nature Medicine in the paper, “CD19 CAR-T cell therapy for treatment-refractory seropositive rheumatoid arthritis: a Phase 1 trial.” RA is a chronic disease with recurrent inflammation and joint swelling which can, as the disease progresses, lead to…...

2+ week, 1+ day ago   (396+ words) By modulating Notch and T cell receptor signaling, scientists have produced functional CD4+ T cells from iPSCs, potentially advancing scalable, off-the-shelf CAR T therapies. The post Notch Signaling Switch Enables Scalable Helper T Cell Production for CAR T appeared first on…...