2+ day, 3+ hour ago   (361+ words) A Salk Institute team has now discovered a novel pathway that links chronic interferon II (IFN-II) exposure to mitochondrial dysfunction that ultimately causes immunosuppression. By explaining how interferon II turns from “good” to “bad,” the foundational insights provide a path…...

2+ day, 6+ hour ago   (433+ words) By Mike May, PhD A key to modern media optimization comes from knowing that different cell types need different media. [Westend61 / Getty Images] Cell culture has come a long way since then. That complexity was the focus of a recent discussion…...

2+ day, 7+ hour ago   (441+ words) As wet-lab validation becomes increasingly important to support artificial intelligence-enhanced science, research science points out that human-relevant cell models provide an important foundation for testing and confirming AI-generated insights. The post Revvity Signs Agreement to Acquire Human Cell Design appeared…...

3+ day, 4+ hour ago   (282+ words) Sandhoff disease, like Tay-Sachs disease, is a fatal neurodegenerative lysosomal storage disease caused by the absence of ß-hexosaminidase (Hex) which leads to the accumulation of GM2 ganglioside in lysosomes. The disease, for which there are no available therapies, results in the…...

3+ day, 4+ hour ago   (430+ words) Scientists developed monoclonal antibodies targeting matrix metalloproteinase-9, which in a newly reported preclinical study slowed and even reversed diabetic nerve damage in mouse models of type I and type II diabetes. The post Monoclonal Antibodies Targeting MMP-9 Alleviate Peripheral Neuropathy…...

3+ day, 6+ hour ago   (422+ words) By Gareth John Macdonald Credit: AscentXmedia / Getty Images Autologous cell therapy production is difficult from an operational standpoint, according to researchers, who say choosing a manufacturing model that addresses the specific logistical and economic challenges of the project involved is…...

3+ day, 6+ hour ago   (165+ words) Overexpressing the cytoplasmic poly(A)-binding protein gene Pabpc1 increases protein titers in Chinese hamster ovary (CHO) cell lines by 30–50%, according to researchers from BeOne Medicines (formerly BeiGene). Those results, published in a recent paper, appear consistent across multispecific and monoclonal antibodies....

4+ day, 37+ min ago   (485+ words) Genetic Engineering and Biotechnology News For decades, RAS proteins have occupied a frustrating place in cancer biology: central to tumor growth, yet difficult to drug. Members of the RAS family—KRAS, NRAS, and HRAS—act as molecular switches that help…...

4+ day, 7+ hour ago   (52+ words) Sponsored content brought to you by 1. Clarke H, et al. Biotechnol Prog. 2024:e3449. doi:10.1002/btpr.3449. 2. Diep J, et al. Biotechnol Prog. 2021;37:e3192. doi:10.1002/btpr.3192. 5. Corrigall H. Bruker Cellular Analysis webinar, 2025. Eric Sackmann, PhD, is a director of product management at Bruker Cellular Analysis....

4+ day, 7+ hour ago   (408+ words) The expanded next-generation sequencing offering from Clean Cells now covers GMP-compliant viral safety testing for viral vectors and recombinant preparations, building on existing identity testing capabilities. The post Clean Cells Broadens Viral Safety Testing Portfolio with NGS appeared first on…...